86 articles - From Saturday Apr 30 2022 to Friday May 06 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Aliment Pharmacol Ther |
The knowledge and skills needed to perform intestinal ultrasound for inflammatory bowel diseases-An international Delphi consensus survey. We established international, expert consensus on the knowledge and skills that should be expected from newly certified IUS practitioners. These consensus statements are the first step towards mastery learning for IUS training. Educators can utilise these statements to design training programmes and evaluate the competencies of trainees before they engage in independent practice. |
| Gastroenterology |
Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Due to the relative rarity of the hamartomatous polyposis syndromes, recommendations for management are based on few studies. This U. S Multi-Society Task Force on Colorectal Cancer consensus statement summarizes the clinical features, assesses the current literature, and provides guidance for diagnosis, assessment, and management of patients with the hamartomatous polyposis syndromes, with a focus on endoscopic management. |
| Gastrointest Endosc |
Diagnosis and management of cancer risk in the gastrointestinal hamartomatous polyposis syndromes: recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer. This U. S. Multi-Society Task Force on Colorectal Cancer consensus statement summarizes the clinical features, assesses the current literature, and provides guidance for diagnosis, assessment, and management of patients with the hamartomatous polyposis syndromes, with a focus on endoscopic management. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
Systematic review-Pancreatic involvement in inflammatory bowel disease. This is the first systematic review of the association between IBD and pancreatic diseases. Gallstones and drugs should be considered the most probable causes of AP in IBD, with type 2 AIP also being possible. |
| Am J Gastroenterol |
Helicobacter pylori Antibiotic Resistance in the United States Between 2011-2021: A Systematic Review and Meta-Analysis. Metronidazole, levofloxacin, and clarithromycin resistance rates each exceed 30%; thus, choosing an empiric antibiotic regimen without knowledge of the likely pattern of antibiotic resistance is not appropriate. Resistance to tetracycline, rifabutin, and amoxicillin remains low. Given the scarcity of available data with considerable heterogeneity among studies, continued surveillance, ideally with a more systematic approach to data collection, is an increasingly important goal in H. pylori management. |
| Hepatology |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Association of golimumab trough concentrations during maintenance with clinical, biological, endoscopic and histologic remission in patients with ulcerative colitis. Golimumab trough concentrations during maintenance are associated with favourable treatment outcomes including endoscopic healing, histologic remission and long-term persistence on golimumab. We identified the optimal golimumab thresholds most closely associated with key outcomes. |
Randomised clinical trial: individual versus group hypnotherapy for irritable bowel syndrome. Nurse-administered gut-directed hypnotherapy, delivered individually or in groups, relieves IBS symptoms, improves psychological symptoms and quality of life. Group hypnotherapy can be an efficacious alternative, enabling more patients to benefit from the treatment (ClinicalTrials.gov ID no of study NCT03432078). |
The efficacy and safety of keverprazan, a novel potassium-competitive acid blocker, in treating erosive oesophagitis: A phase III, randomised, double-blind multicentre study. This study demonstrated the non-inferior efficacy of keverprazan to lansoprazole in treating EO. The incidences of drug-related AEs were comparable between keverprazan and lansoprazole. |
| Am J Gastroenterol |
Mechanisms underlying food-triggered symptoms in disorders of gut-brain interactions. This review highlights emerging mechanisms related to nutrient sensing and tasting, maldigestion, physical effects with underlying visceral hypersensitivity, allergy and immune mechanisms, food - microbiota interactions and gut-brain signaling, with a focus on patients with functional dyspepsia and irritable bowel syndrome. Many patients suffering from DGBI exhibit these mechanism(s) but which ones and which specific properties may vary widely from patient to patient. Thus, in addition to identifying these mechanisms and the need for further studies, biomarkers and novel therapeutic targets are identified that could enable enriched patient groups to be studied in future clinical trials examining the role of food in the generation of gut and non-gut symptoms. |
Proton pump inhibitors and risk of cardiovascular disease: a self-controlled case series study. Negative findings in the SCCS design suggest that association between increased cardiovascular risk and PPI, frequently reported in prior observational studies, is likely due to residual confounding related to conditions with PPI treatment, rather than a true relationship. |
| Clin Gastroenterol Hepatol |
Nomenclature dilemma of metabolic associated fatty liver disease (MAFLD): Considerable proportions of MAFLD are metabolic healthy. Contrary to the definition of MAFLD, a non-negligible number of metabolically healthy individuals are included in the MAFLD group. The metabolic healthy MAFLD group showed a comparable fibrosis burden and prevalence of carotid artery plaque compared to the healthy control group. |
Retreatment with Checkpoint inhibitors after a severe immune-related hepatitis: Results from a prospective multicenter study. Retreatment with CPIs is a feasible option after a severe immune-related hepatitis, even with the same CPIs, without recurrence of the liver injury retreatment in up to 65% of patients. |
| Endoscopy |
Risk of recurrence after endoscopic resection of nonpedunculated T1 colorectal cancer. Tumor recurrence was rare (4.7 |
| Gastroenterology |
Post-acute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases. Our results indicate that SARS-CoV-2 antigen persistence in infected tissues serves as a basis for post-acute COVID-19. The concept that viral antigen persistence instigates immune perturbation and post-acute COVID-19 requires validation in controlled clinical trials. |
Prediction models for celiac disease development in children from high-risk families: Data from the PreventCD cohort. Children with CD-FDR develop CD early in life, and their risk depends on gender, age and HLA-DQ all factors which are important for a sound screening advice. These children should be screened early in life, including HLA-DQ2/8-typing, and if genetically predisposed to CD, should get further personalized screening advice using our Prediction app. |
ß-Catenin sustains and is required for YES-associated protein oncogenic activity in cholangiocarcinoma. YAP induces cholangiocarcinogenesis via TEAD-dependent transcriptional activation and interaction with ß-Catenin. ß-Catenin binds to YAP in iCCA and is required for YAP full transcriptional activity, revealing the functional crosstalk between YAP and ß-Catenin pathways in cholangiocarcinogenesis. |
Toll Like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-Induced Gastric Metaplasias. TLR9 plays an essential role in the production of IFNa and polarization of SLFN + -MDSCs upon Helicobacter infection. Subjects carrying the rs5743836 TLR9 minor C allele are predisposed to neoplastic complications if chronically infected. |
| Gastrointest Endosc |
Evaluation of Endoscopic Gastrojejunostomy Revision Following Roux-en-Y Gastric Bypass for Treatment of Dumping Syndrome. EGJR is associated with effective and durable resolution of dumping at 3 years post-operatively, with minimal long-term impact on weight loss. The presence of GERD pre-operatively correlates to a statistically significant resolution of dumping. |
Improved adenoma detection by a novel distal attachment device-assisted colonoscopy: A prospective randomized controlled trial. WingCap-assisted colonoscopy was tolerable and efficacious for improving ADR and APC compared to standard colonoscopy, especially for non-pedunculated, diminutive adenomas and for beginner endoscopists. |
Narrow Band Imaging for Diagnosis of Non-Erosive Reflux Disease: An International, Multicenter, Randomized Controlled Trial. In this RCT, ridge-villous pattern on NBI demonstrated a high specificity, correlated with acid exposure time and improved with proton pump inhibitor therapy suggesting that it could be used as a surrogate marker for diagnosis of non-erosive reflux disease.( NCT02081404). |
| Hepatology |
Pharmaceutical Shp2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity. These results unveil complex mechanisms for the tumor-suppressing effect of pharmaceutical Shp2 inhibition in the liver immune environment. We provide a proof of principle for clinical trial with specific Shp2 inhibitors in primary and metastasized liver cancer patients. |
Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Anlotinib combined with TQB2450 showed promising efficacy and was well tolerated in advanced BTCs. KRAS mutation and high TMB might serve as predictors of treatment efficacy. |
| Inflamm Bowel Dis |
Sex-related Differences in Inflammatory Bowel Diseases: The Potential Role of Sex Hormones. Additionally, the potential role of sex hormones in the modulation of gut microbiota is attracting increasing attention. Here, we discuss the sex dimorphic disease profile and address the potential mechanisms involved in the sex-specific pathogenesis of IBD. Improved understanding of these sex differences in the clinic could improve the knowledge of patients with IBD with heterogeneous disease profiles. |
| J Crohns Colitis |
| Neurogastroenterol Motil |
Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids. Fecal luminal factors from IBS patients induce a distinct colonic epithelial gene expression, potentially reflecting the disease pathophysiology. The culture of colonoids from healthy subjects with fecal supernatants from IBS patients may facilitate the exploration of IBS related intestinal micro-environmental and barrier interactions. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Hepatology |
Machine Perfusion in Liver Transplantation. To achieve this, machine liver perfusion, a procedure developed more than 50 years ago but almost forgotten at the end of the last century, is again of great interest. We describe in this review the clinical most applied machine perfusion techniques, their mechanistic background, and a novel concept of combining immediate organ assessment during hypothermic oxygenated perfusion (HOPE), followed by an extended phase of normothermic machine perfusion, with simultaneous ex situ treatment of the perfused liver. Such a new approach may allow to dramatically increase the pool of usable livers and improve outcomes for recipients. |
| J Hepatol |
Letters to the editors and authors’ replies
| Gastroenterology |
| Gut |
| Hepatology |
| J Hepatol |
all remaining publications eg case reports, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |